Structure de mise en forme 2 colonnes

University of Portsmouth – School of Biological Sciences

Combining the expertise from the various disciplines, the researchers at the School co-operate to address some of the key environmental and medical issues that we face in the new century, and to advance our knowledge of biological processes.
The School of Biological Sciences has an established international reputation for both fundamental and applied research. Over 30 academic staff, more than 60 postdoctoral and postgraduate researchers and undergraduate project students are engaged in the research programmes. Our research activities cover a wide range of interests from the molecular level to the environment, reflecting the complexity of the modern biological sciences.
The School attracts funding from many sources including industry, Research Councils, The Wellcome Trust, Leverhulme Trust, Cancer Research UK, government agencies and the European Union, totalling many millions of pounds.

Role/activity of the entity in the project:

Our main role regarding this project is to evaluate the bioactivity of new marine natural products obtained from algae. Our lab-based bioassays target marine organisms involved in biofouling of marine structures. For this purpose, the organisms studied are bacteria, fungi, microalgae, macroalgae and invertebrates). Particular attention is given to the adhesion inhibition.
Human and marine pathogenic microorganisms such as Staphyloccocus and Vibrios, are also utilised in areas of research.


Key people involved in the project :


Principal Investigator: Dr Claire Hellio, Reader in Environmental Microbiology
Senior Research Technician: Jo Pope, Microbiologist
Research Associate: Rozenn Trepos (Bsc, Msc), Marine Natural Product Chemist


Publications/recent patents :

Gastineau, R., Pouvreau, J.B., Hellio, Claire, Morancais, M., Fleurence, J., Gaudin, P., Bourgougnon, N., Mouget, J.L. (2012). Biological activities of purified marennine, the blue pigment responsible for the greening of oysters. Journal of Agriculture and Food Chemistry. In press

Marechal, J-P. and Hellio, Claire (2011) Antifouling activity against barnacle cypris larvae: Do target species matter (Amphibalanus amphitrite versus Semibalanus balanoides)? International Biodeterioration and Biodegradation, 65 (1). pp. 92-101. ISSN 0964-8305 10.1016/j.ibiod.2010.10.002

Bayer, M., Hellio, Claire, Marechal, J-P., Lin, W., Frank, W., Weber, H. and Proksch, P. (2011) Antifouling bastadin congeners target blue mussel phenoloxidase and complex copper(II) ions. Marine Biotechnology. ISSN 1436-2228 10.1007/s10126-011-9378-3

Saddiqe, Z., Naeem, I., Maimoona, A., Patel, Asmita and Hellio, Claire (2011) Assay of flavonoid aglycones with HPLC in four species of genus Hypericum. Journal of Medicinal Plants Research, 5 (9). pp. 1526-1530. ISSN 1996-0875

Chambers, L., Hellio, Claire, Stokes, K., Dennington, S., Goodes, L., Wood, R. and Walsh, F. (2011) Investigation of Chondrus crispus as a potential source of new antifouling agents. International Biodeterioration & Biodegradation. ISSN 0964-8305 10.1016/j.ibiod.2011.07.002

Thabard, Marie, Gros, O., Hellio, Claire and Marechal, J-P. (2011) Sargassum polyceratium (Phaeophyceae, Fucaceae) surface molecule activity towards fouling organisms and embryonic development of benthic species. Botanica Marina, 54. pp. 147-157. ISSN 0006-8055 10.1515/BOT.2011.014

Kientz, B., Thabard, Marie, Cragg, Simon, Pope, Jo and Hellio, Claire (2011) A new method for removing microflora from macroalgal surfaces: an important step for natural product discovery. Botanica Marina, 54. ISSN 0006-8055 10.1515/BOT.2011.053

Naeem, I., Saddiqe, Z., Sautreau, Asmita and Hellio, Claire (2010) Analysis of flavonoid and antimicrobial activity of extracts of Hypericum perforatum. Asian Journal of Chemistry, 22 (5). pp. 3596-3600. ISSN 0970-7077

Plouguerne, E., Ioannou, E., Georgantea, P., Vagias, C., Roussis, V., Hellio, Claire, Kraffe, E. and Stiger-Pouvreau, V. (2010) Anti-microfouling activity of lipidic metabolites from the invasive brown alga Sargassum muticum (Yendo) Fensholt. Marine Biotechnology, 12 (1). pp. 52-61. ISSN 1436-2228 10.1007/s10126-009-9199-9

Plouguerne, E., Hellio, Claire, Cesconetto, C., Thabard, M., Mason, K., Veron, B., Pereira, R. and Da Gama, B. (2010) Antifouling activity as a function of population variation in Sargassum vulgare from the littoral of Rio de Janeiro (Brazil). Journal of Applied Phycology, 22 (6). pp. 717-724. ISSN 0921-8971 10.1007/s10811-010-9511-0

Bressy, C., Hellio, Claire, Marechal, J., Tanguy, R. and Margaillan, A. (2010) Bioassays and field immersion test: A comparison of marine antifouling activity of copper-free poly(methacrylic)-based coatings containing tertiary amines and ammonium salt groups. Biofouling, 26 (7). pp. 769-777. ISSN 0892-7014 10.1080/08927014.2010.516392

Hellio, Claire (2010) The potential of marine biotechnology for the development of new antifouling solutions. Journal des Sciences Halieutique et Aquatique, 2. pp. 35-41.

Hellio, Claire and Yebra, D. (2009) Advances in marine antifouling coatings and technologies. Woodhead Publishing, Cambridge. ISBN 1845693868

Marechal, J. and Hellio, Claire (2009) Challenges for the development of new non-toxic antifouling solutions. International Journal of Molecular Sciences, 10 (11). pp. 4623-4637. ISSN 1422-0067 10.3390/Ijms10114623

Thabard, Marie, Iddaoud, Ghezlane, Veron, B., Fletcher, Bob and Hellio, Claire (2009) Screening of biological activities of extracts of Ralfsia verrucosa, Petalonia fascia and Scytosiphon lomentaria (Phaeophyceae, Scytosiphonales) for potential antifouling application. Electronic Journal of Natural Substances, 4. pp. 1-10. ISSN 1951-6193

Hellio, Claire (2009) The search for antifouling substances. Biofutur, 28 (301). p. 48. ISSN 0294-3506

Plouguerne, E., Hellio, Claire, Deslandes, E., Veron, B. and Stiger-Pouvreau, V. (2008) Anti-microfouling activities in extracts of two invasive algae: Grateloupia turuturu and Sargassum muticum. Botanica Marina, 51 (3). pp. 202-208. ISSN 0006-8055 10.1515/Bot.2008.026

Culioli, G., Ortalo-Magne, A., Valls, R., Hellio, Claire, Clare, A. and Piovetti, L. (2008) Antifouling activity of meroditerpenoids from the marine brown alga Halidrys siliquosa. Journal of Natural Products, 71 (7). pp. 1121-1126. ISSN 0163-3864 10.1021/Np070110k

Mokrini, R., Ben Mesaoud, M., Daoudi, M., Hellio, Claire, Marechal, J., El Hattab, M., Ortalo-Magne, A., Piovetti, L. and Culioli, G. (2008) Meroditerpenoids and derivatives from the brown alga Cystoseira baccata and their antifouling properties. Journal of Natural Products, 71 (11). pp. 1806-1811. ISSN 0163-3864 10.1021/np8004216

Tsoukatou, M., Marechal, J., Hellio, Claire, Novakovic, I., Tufegdzie, S., Sladic, D., Gasic, M., Clare, A., Vagias, C. and Roussis, V. (2007) Evaluation of the activity of the sponge metabolites avarol and avarone and their synthetic derivatives against fouling micro- and macroorganisms. Molecules, 12 (5). pp. 1022-1034. ISSN 1420-3049 10.3390/12051022

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